Epidemiologic features in mesothelioma

Easy guide to know epidemiologic features in mesothelioma The rising worldwide incidence of malignant mesothelioma is not expected to peak for another 10 to 20 years. It is possible that the disease has already reached its peak incidence in the United States,24 whereas the anticipated peaks in Europe...
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Causes of malignant mesothelioma

New guide to know causes of malignant mesothelioma Asbestos is the principal carcinogen associated with  causes of malignant mesothelioma. Indeed, malignant mesothelioma was rare before the widespread use of asbestos. In 1960 the first convincing evidence of a link between malignant mesothelioma and both occupational and incidental asbestos...
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Malignant mesothelioma

Advances in malignant mesothelioma Malignant mesothelioma is an aggressive tumor of serosal surfaces, such as the pleura and the peritoneum. This tumor was once rare, but its incidence is increasing worldwide, probably as a result of widespread exposure to asbestos, a factor with which it is associated (Table...
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Bel-XL and Bel-2 treatment of mesothelioma

Guide to get Bcl-XL and Bcl-2 treatment of mesothelioma Conventional chemotherapeutic agents and radiation therapy have been shown to exert their cytotoxic effects by inducing apoptosis via the mitochondrial (intrinsic) pathway (Figure 3),Alterations in expression levels of genes and proteins that regulate this pathway of programmed cell death...
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Chromosomal alterations of mesothelioma

Guide of chromosomal alterations of mesothelioma symptoms Allele loss, with subsequent loss of heterozygosity (LOH) at tumor suppressor loci, is a common occurrence in oncogenesis. Mutations and deletions of the p53 and pRb tumor suppressor pathways are prominent features in many human malignancies; however, p53 and pRb remain...
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SV40 in human mesotheliomas

SIMIAN VIRUS 40 in human mesotheliomas SV40 is a DNA tumor virus that has been associated with the development of malignant mesothelioma. Although this virus is endogenous in rhesus monkeys, epidemiologic studies have shown that it is widespread among the human population. The modes by which the virus...
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Asbestos

Etiology of mesothelioma – asbestos The vast majority of cases of mesothelioma can be linked in some fashion to asbestos exposure. Materials utilizing asbestos fibers have been present since ancient times. In fact, the word asbestos is derived from a Greek term meaning inextinguishable or unquenchable, a reference...
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Malignant pleural mesothelioma

Molecular Pathogenesis of Malignant Pleural Mesothelioma Malignant mesothelioma is a rare, highly aggressive cancer which arises from the mesothelial cells which form the lining of the pleural, and less frequently the peritoneal cavities. Malignant pleural mesothelioma (MPM) is an emergent neoplasm, as it was rarely diagnosed prior to...
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Mesothelioma Chemotherapy

Mesothelioma chemotherapy of intraperitoneal The use of intraperitoneal chemotherapy for mesothelioma has been extensively reviewed by Antman et al. and Markman. Intraperitoneal cisplatin and intravenous thiosulfate protection have resulted in a 59% complete response rate. However, many patients have relapsed quickly after treatment, implying incomplete eradication of tumor using...
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